How do you best apply an Embark health variant test result to your breeding program or to an individual dog’s health care? When our veterinary geneticists and professional services team at Embark field questions like these, our answers are always based on the scientific research behind the health variant in question, as well as the breed of dog tested. We asked our experts to share answers to common questions about the tested variant for Degenerative Myelopathy (SOD1A).
What is Degenerative Myelopathy (DM)?
A disease of mature dogs, DM is a progressive degenerative disorder of the spinal cord that can cause muscle wasting and gait abnormalities. Affected dogs do not usually show signs until they are at least 8 years old, where the first signs of neural degeneration appear in the nerves that innervate the hind limbs. An affected dog may scuff the tops of their hind paws or walk with a hesitant, exaggerated gait.
In advanced cases, lower motor neurons are also affected leading to weakness and muscle wasting. This variant is reported to have incomplete penetrance, meaning not all dogs with two copies of the variant will go on to develop clinical signs and other genetic and environmental factors will contribute to whether a dog develops DM. Furthermore, this variant is only known to increase the risk of DM in certain breeds. Other breeds where this variant occurs but is not associated with DM risk likely have genetic factors protecting them from this disease.
My dog has two copies of…
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